2026.04Vancouver
Jongmin Lee
bioinformatics, biology with root access.

I build gene therapies the way I build software: from first principles, source open, no ceremony.

ε-sarcoglycan (SGCE) ribbon, AlphaFold prediction AF-O43556
Fig. 1 — ε-sarcoglycan (SGCE), wild-type. AlphaFold prediction AF-O43556 (UniProt O43556). Interactive viewer at arcivus.ca/explorer.
NOW
BUILDING
AAV gene-replacement therapy for DYT-SGCE myoclonus-dystonia at Arcivus Lab.
STUDYING
Bioinformatics @ Langara (3.7 GPA). UBC Microbiology and Immunology, 2027 intake.
OPEN TO
Wet-lab partners for AAV production. Bioinformatics consulting (Python / LLM pipelines).
THESIS

Patient-specific molecular identity should drive therapy design, not population averages.

The concrete test case is a single frameshift in the SGCE gene1 — one nucleotide duplicated, one premature stop codon, one truncated ε-sarcoglycan. Arcivus Lab's first program is an AAV vector that replaces the broken copy. No small molecules. No symptom management.

NorthProt is the silicon half: Python, Claude API, MCP pipelines, pgvector retrieval over the primary literature. Arcivus is the carbon half: capsid engineering, construct design, wet-lab validation. The same person runs both sides because the target-identification-to-construct gap2 is where rare-disease programs die, and collapsing it is a tooling problem before it is a biology problem.

From first principles, source open, no ceremony3 — this is how the work is done, not how the site is marketed. Every tool Arcivus builds ships open-source. Every decision is traceable to a paper or a sequence. Small. Real.

WORK
Arcivus LabCo-FounderMar 2026 — present

AAV gene-replacement therapy for DYT-SGCE myoclonus-dystonia.

  • AAV
  • AlphaFold
  • Structural bio
NorthProtFounderNov 2025 — present

Solo R&D lab. Carbon and Silicon. 100% upstream of Arcivus.

  • Python
  • Claude API
  • MCP
  • pgvector
SGCE ε-Sarcoglycan ExplorerAuthorMar 2026 — present

Open-source 3D visualization of the SGCE protein for understanding the DYT-SGCE c.108dup mutation.

  • Next.js
  • 3Dmol.js
Brightspace MCPAuthorMar 2026

Open-source MCP server for Brightspace LMS — automated coursework retrieval via Playwright.

  • Python
  • MCP
  • Playwright
WRITING

Striatal D2 Receptor Upregulation in Myoclonus-Dystonia: A Review

Jan 12, 2025

Myoclonus-dystonia is a SGCE-driven movement disorder with reduced striatal D2 receptor density and excessive dopamine release. Restoring D2 signaling — pharmacologically, genetically, or via lifestyle — is a plausible therapeutic axis, and the review surveys the evidence for each.

STACK
LANGUAGES
PythonTypeScriptSQL
BIO
BLASTAlphaFoldVariant annotation
AI
Claude APIMCPVoyage embeddings
DATA
PostgreSQL + pgvectorRAG
WEB
Next.jsReactTailwind v4Vercel
OS
Fedora 43Pop!_OS
CERTS
MCP Advanced (Anthropic, 2026)Building with the Claude API (2026)
ELSEWHERE

This page was designed and implemented end-to-end by Claude (Opus 4.6). Sourcing, copy decisions, layout, and code generation were all model-driven from a single brief. The human pipeline — review, deploy, infrastructure — is by Cyan.

Set in Source Serif 4 and JetBrains Mono. Cream paper. Cool ink. ε-sarcoglycan ribbon from AlphaFold prediction AF-O43556; 3Dmol.js on desktop.

Source on GitHub© 2026 NorthProt